HIV-1 Tropism Determination Using a Phenotypic Env Recombinant Viral Assay Highlights Overestimation of CXCR4-Usage by Genotypic Prediction Algorithms for CRRF01_AE and CRF02_AG

BACKGROUND: Human Immunodeficiency virus type-1 (HIV) entry into target cells involves binding of the viral envelope (Env) to CD4 and a coreceptor, mainly CCR5 or CXCR4. The only currently licensed HIV entry inhibitor, maraviroc, targets CCR5, and the presence of CXCX4-using strains must be excluded...

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Main Authors: Mulinge, Martin, Lemaire, Morgane, Servais, Jean-Yves, Rybicki, Arkadiusz, Struck, Daniel, da Silva, Eveline Santos, Verhofstede, Chris, Lie, Yolanda, Seguin-Devaux, Carole, Schmit, Jean-Claude, Bercoff, Danielle Perez
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648519/
https://ncbi.nlm.nih.gov/pubmed/23667426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060566
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