ロード中...

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins.

In Philadelphia chromosome-positive human leukemias, the c-abl proto-oncogene on chromosome 9 becomes fused to the bcr gene on chromosome 22, and chimeric Bcr-Abl proteins are produced. The fused Bcr sequences activate the tyrosine kinase, actin-binding, and transforming functions of Abl. Activation...

詳細記述

保存先:
書誌詳細
出版年:Mol Cell Biol
主要な著者: McWhirter, J R, Galasso, D L, Wang, J Y
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 1993
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364830/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8246975/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.12.7587
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!