Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo.

The human trkA cDNA was transfected into a malignant human neuroblastoma (NB) cell line (HTLA230) to investigate its role in NB growth and differentiation. This cell line lacks expression of both endogenous trkA and gp75NGFR genes. Transfectants expressing the trkA mRNA and surface-bound receptors t...

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Bibliographic Details
Main Authors: Matsushima, H, Bogenmann, E
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC364816/
https://ncbi.nlm.nih.gov/pubmed/8246962
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