The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.

EWS/FLI-1 is a chimeric protein formed by a tumor-specific 11;22 translocation found in both Ewing's sarcoma and primitive neuroectodermal tumor of childhood. EWS/FLI-1 has been shown to be a potent transforming gene, suggesting that it plays an important role in the genesis of these human tumo...

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Bibliographic Details
Main Authors: May, W A, Lessnick, S L, Braun, B S, Klemsz, M, Lewis, B C, Lunsford, L B, Hromas, R, Denny, C T
Format: Artigo
Language:Inglês
Published: 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC364810/
https://ncbi.nlm.nih.gov/pubmed/8246959
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