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HuR Maintains a Replicative Life Span by Repressing the ARF Tumor Suppressor
p19(ARF) plays an essential role in the senescence of mouse cells, and its expression is lost by methylation or deletion of the ARF locus; otherwise, p53 is inactivated to bypass senescence. ARF expression is tightly regulated, but little is known about its posttranscriptional regulation. Here, we s...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3647966/ https://ncbi.nlm.nih.gov/pubmed/23508105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01277-12 |
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