The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.

The catalytic function of Src-related tyrosine protein kinases is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies suggest that this inhibitory event is not the result of autophosphorylation but that it is mediated by another cytoplasmic tyrosine protein...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Gervais, F G, Chow, L M, Lee, J M, Branton, P E, Veillette, A
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364772/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413300/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.11.7112
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