The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.

Benzer Materyaller

• The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytes.
  Yazar:: Gervais, F G, ve diğerleri
  Baskı/Yayın Bilgisi: (1995)
• The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.
  Yazar:: Bergman, M, ve diğerleri
  Baskı/Yayın Bilgisi: (1992)
• Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions
  Yazar:: Kästle, Matthias, ve diğerleri
  Baskı/Yayın Bilgisi: (2020)
• Tyrosine Phosphorylation in the SH3 Domain Disrupts Negative Regulatory Interactions within the c-Abl Kinase Core
  Yazar:: Chen, Shugui, ve diğerleri
  Baskı/Yayın Bilgisi: (2008)
• CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.
  Yazar:: Sieh, M, ve diğerleri
  Baskı/Yayın Bilgisi: (1993)