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Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1
Tight junctions (TJs) regulate the paracellular movement of ions, macromolecules and immune cells across epithelia. Zonula occludens (ZO)-1 is a multi-domain polypeptide required for the assembly of TJs. MDCK II cells lacking ZO-1, and its homolog ZO-2, have three distinct phenotypes: reduced locali...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3647435/ https://ncbi.nlm.nih.gov/pubmed/23418357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.113399 |
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