Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1

Tight junctions (TJs) regulate the paracellular movement of ions, macromolecules and immune cells across epithelia. Zonula occludens (ZO)-1 is a multi-domain polypeptide required for the assembly of TJs. MDCK II cells lacking ZO-1, and its homolog ZO-2, have three distinct phenotypes: reduced locali...

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Hlavní autoři: Rodgers, Laurel S., Beam, M. Tanner, Anderson, James M., Fanning, Alan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647435/
https://ncbi.nlm.nih.gov/pubmed/23418357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.113399
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