Elevated PCSK9 Levels in Untreated Patients With Heterozygous or Homozygous Familial Hypercholesterolemia and the Response to High‐Dose Statin Therapy

BACKGROUND: Proprotein convertase subtilisin kexin type 9 (PCSK9) is an enzyme that impairs low‐density lipoprotein cholesterol (LDL‐C) clearance from the plasma by promoting LDL receptor degradation. Patients with familial hypercholesterolemia (FH) have reduced or absent LDL receptors and should th...

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Bibliografiske detaljer
Main Authors: Raal, Frederick, Panz, Vanessa, Immelman, Andrew, Pilcher, Gillian
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647281/
https://ncbi.nlm.nih.gov/pubmed/23537802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.000028
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