Therapeutic Cardiac‐Targeted Delivery of miR‐1 Reverses Pressure Overload–Induced Cardiac Hypertrophy and Attenuates Pathological Remodeling

BACKGROUND: MicroRNAs (miRNAs) play a key role in the development of heart failure, and recent studies have shown that the muscle‐specific miR‐1 is a key regulator of cardiac hypertrophy. We tested the hypothesis that chronic restoration of miR‐1 gene expression in vivo will regress hypertrophy and...

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Detalhes bibliográficos
Main Authors: Karakikes, Ioannis, Chaanine, Antoine H., Kang, Soojeong, Mukete, Bertrand N., Jeong, Dongtak, Zhang, Shihong, Hajjar, Roger J., Lebeche, Djamel
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647279/
https://ncbi.nlm.nih.gov/pubmed/23612897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000078
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