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Comparison of responses of human melanoma cell lines to MEK and BRAF inhibitors
The NRAS and BRAF genes are frequently mutated in melanoma, suggesting that the NRAS-BRAF-MEK-ERK signaling pathway is an important target for therapy. Two classes of drugs, one targeting activated BRAF and one targeting MEK, are currently undergoing clinical evaluation. We have analysed the NRAS an...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3647113/ https://ncbi.nlm.nih.gov/pubmed/23658559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2013.00066 |
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