Comparison of responses of human melanoma cell lines to MEK and BRAF inhibitors

The NRAS and BRAF genes are frequently mutated in melanoma, suggesting that the NRAS-BRAF-MEK-ERK signaling pathway is an important target for therapy. Two classes of drugs, one targeting activated BRAF and one targeting MEK, are currently undergoing clinical evaluation. We have analysed the NRAS an...

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Detalhes bibliográficos
Main Authors: Stones, Clare J., Kim, Ji Eun, Joseph, Wayne R., Leung, Euphemia, Marshall, Elaine S., Finlay, Graeme J., Shelling, Andrew N., Baguley, Bruce C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647113/
https://ncbi.nlm.nih.gov/pubmed/23658559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2013.00066
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