Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

We report a strategy for regulating the activity of a cytoplasmic signaling molecule, the protein kinase encoded by raf-1. Retroviruses encoding a gene fusion between an oncogenic form of human p74raf-1 and the hormone-binding domain of the human estrogen receptor (hrafER) were constructed. The fusi...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Samuels, M L, Weber, M J, Bishop, J M, McMahon, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364683/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.10.6241-6252.1993
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