Imbalance between Neutrophil Elastase and its Inhibitor α1-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure

The molecular mechanisms involved in the development of obesity and related complications remain unclear. Here, we report that obese mice and human subjects have increased activity of neutrophil elastase (NE) and decreased serum levels of the NE inhibitor, α1-antitrypsin (A1AT, SerpinA1). NE null (E...

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Bibliographische Detailangaben
Hauptverfasser: Mansuy-Aubert, Virginie, Zhou, Qiong L., Xie, Xiangyang, Gong, Zhenwei, Huang, Jun-Yuan, Khan, Abdul R., Aubert, Gregory, Candelaria, Karla, Thomas, Shantele, Shin, Dong-Ju, Booth, Sarah, Baig, Shahid M., Bilal, Ahmed, Hwang, Daehee, Zhang, Hui, Lovell-Badge, Robin, Smith, Steven R., Awan, Fazli R., Jiang, Zhen Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646573/
https://ncbi.nlm.nih.gov/pubmed/23562077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.03.005
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