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Dynamic Nuclear Polarization Study of Inhibitor Binding to the M2(18–60) Proton Transporter from Influenza A
We demonstrate the use of dynamic nuclear polarization (DNP) to elucidate ligand binding to a membrane protein using dipolar recoupling magic angle spinning (MAS) NMR. In particular, we detect drug binding in the proton transporter M2(18–60) from influenza A using recoupling experiments at room temp...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3646523/ https://ncbi.nlm.nih.gov/pubmed/23480101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400150x |
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