Nitric oxide–mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection

Nitric oxide (NO) generated by inducible NO synthase 2 (NOS2) affects cellular iron homeostasis, but the underlying molecular mechanisms and implications for NOS2-dependent pathogen control are incompletely understood. In this study, we found that NO up-regulated the expression of ferroportin-1 (Fpn...

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Hauptverfasser: Nairz, Manfred, Schleicher, Ulrike, Schroll, Andrea, Sonnweber, Thomas, Theurl, Igor, Ludwiczek, Susanne, Talasz, Heribert, Brandacher, Gerald, Moser, Patrizia L., Muckenthaler, Martina U., Fang, Ferric C., Bogdan, Christian, Weiss, Günter
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646493/
https://ncbi.nlm.nih.gov/pubmed/23630227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121946
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