Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes

CD4(+) memory cell development is dependent upon T cell receptor (TCR) signal strength, antigen dose and the cytokine milieu, all of which are altered in type 1 diabetes (T1D). We hypothesized that CD4(+) T cell turnover would be greater in type 1 diabetes subjects compared to controls. In vitro stu...

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Detalhes bibliográficos
Main Authors: Bollyky, J B, Long, S A, Fitch, M, Bollyky, P L, Rieck, M, Rogers, R, Samuels, P L, Sanda, S, Buckner, J H, Hellerstein, M K, Greenbaum, C J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646435/
https://ncbi.nlm.nih.gov/pubmed/23600824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12064
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