Chemical and Biological Consequences of Oxidatively Damaged Guanine in DNA

Of the four native nucleosides, 2′-deoxyguanosine (dGuo) is most easily oxidized. Two lesions derived from dGuo are 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy)·dGuo. Furthermore, while steady-state levels of 8-oxodGuo can be detected in geno...

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Bibliographic Details
Main Authors:	Delaney, Sarah, Jarem, Daniel A., Volle, Catherine B., Yennie, Craig J.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3646368/ https://ncbi.nlm.nih.gov/pubmed/22239655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2011.653968
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Chemical and Biological Consequences of Oxidatively Damaged Guanine in DNA

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