GroEL and CCT are catalytic unfoldases mediating out-of-cage polypeptide refolding without ATP

Chaperonins are cage-like complexes in which nonnative polypeptides prone to aggregation are thought to reach their native state optimally. However, they also may use ATP to unfold stably bound misfolded polypeptides and mediate the out-of-cage native refolding of large proteins. Here, we show that...

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Bibliographic Details
Main Authors: Priya, Smriti, Sharma, Sandeep Kumar, Sood, Vishal, Mattoo, Rayees U. H., Finka, Andrija, Azem, Abdussalam, De Los Rios, Paolo, Goloubinoff, Pierre
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645539/
https://ncbi.nlm.nih.gov/pubmed/23584019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219867110
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