Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Tumor-derived exosomes are emerging mediators of tumorigenesis with tissue-specific addresses and messages. We explored the function of melanoma-derived exosomes in the formation of primary tumor and metastases in mouse and human subjects. Exosomes from highly metastatic melanoma increased the metas...

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Detalhes bibliográficos
Main Authors: Peinado, Héctor, Alečković, Maša, Lavotshkin, Simon, Matei, Irina, Costa-Silva, Bruno, Moreno-Bueno, Gema, Hergueta-Redondo, Marta, Williams, Caitlin, García-Santos, Guillermo, Nitadori-Hoshino, Ayuko, Hoffman, Caitlin, Badal, Karen, Garcia, Benjamin A., Callahan, Margaret K., Yuan, Jianda, Martins, Vilma R., Skog, Johan, Kaplan, Rosandra N., Brady, Mary S., Wolchok, Jedd D., Chapman, Paul B., Kang, Yibin, Bromberg, Jacqueline, Lyden, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645291/
https://ncbi.nlm.nih.gov/pubmed/22635005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2753
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