Phase II Study of Androgen Synthesis Inhibition with Ketoconazole, Hydrocortisone, and Dutasteride in Asymptomatic Castration-Resistant Prostate Cancer

PURPOSE: Increasing evidence indicates that enhanced intratumoral androgen synthesis contributes to prostate cancer progression after androgen deprivation therapy. This phase II study was designed to assess responses to blocking multiple steps in androgen synthesis with inhibitors of CYP17A1 (ketoco...

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Detalhes bibliográficos
Main Authors: Taplin, Mary-Ellen, Regan, Meredith M., Ko, Yoo-Joung, Bubley, Glenn J., Duggan, Stephen E., Werner, Lillian, Beer, Tomasz M., Ryan, Christopher W., Mathew, Paul, Tu, Shi-Ming, Denmeade, Samuel R., Oh, William K., Sartor, Oliver, Mantzoros, Christos S., Rittmaster, Roger, Kantoff, Philip W., Balk, Steven P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644858/
https://ncbi.nlm.nih.gov/pubmed/19887483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1722
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