VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

Vascular endothelial growth factor (VEGF) guides the path of new vessel sprouts by inducing VEGF receptor-2 activity in the sprout tip. In the stalk cells of the sprout, VEGF receptor-2 activity is downregulated. Here, we show that VEGF receptor-2 in stalk cells is dephosphorylated by the endotheliu...

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Main Authors: Hayashi, Makoto, Majumdar, Arindam, Li, Xiujuan, Adler, Jeremy, Sun, Zuyue, Vertuani, Simona, Hellberg, Carina, Mellberg, Sofie, Koch, Sina, Dimberg, Anna, Young Koh, Gou, Dejana, Elisabetta, Belting, Heinz-Georg, Affolter, Markus, Thurston, Gavin, Holmgren, Lars, Vestweber, Dietmar, Claesson-Welsh, Lena
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644080/
https://ncbi.nlm.nih.gov/pubmed/23575676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2683
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