Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes

Nucleotide excision DNA repair is mechanistically conserved across all kingdoms of life. In prokaryotes, this multi-enzyme process requires six proteins: UvrA–D, DNA polymerase I and DNA ligase. To examine how UvrC locates the UvrB–DNA pre-incision complex at a site of damage, we have labeled UvrB a...

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Bibliographic Details
Main Authors: Hughes, Craig D., Wang, Hong, Ghodke, Harshad, Simons, Michelle, Towheed, Atif, Peng, Ye, Van Houten, Bennett, Kad, Neil M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643590/
https://ncbi.nlm.nih.gov/pubmed/23511970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt177
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