Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats

The type II restriction endonuclease TseI recognizes the DNA target sequence 5′-G^CWGC-3′ (where W = A or T) and cleaves after the first G to produce fragments with three-base 5′-overhangs. We have determined that it is a dimeric protein capable of cleaving not only its target sequence but also one...

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Autori principali: Ma, Long, Chen, Kai, Clarke, David J., Nortcliffe, Christopher P., Wilson, Geoffrey G., Edwardson, J. Michael, Morton, A. Jennifer, Jones, Anita C., Dryden, David T. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643589/
https://ncbi.nlm.nih.gov/pubmed/23525471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt176
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