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Phase II Trial of Sorafenib in Patients with Advanced Anaplastic Carcinoma of the Thyroid
BACKGROUND: Anaplastic thyroid cancer (ATC) is a rare but highly aggressive malignancy with a median survival of 3–5 months. The BRAF oncogene is mutated to its active form in up to 24% of ATC cases. Sorafenib is a tyrosine kinase inhibitor that acts on the RAF-1 serine/threonine kinase. In preclini...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3643255/ https://ncbi.nlm.nih.gov/pubmed/23113752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2012.0103 |
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