Inorganic Pyrophosphatase Defects Lead to Cell Cycle Arrest and Autophagic Cell Death through NAD(+) Depletion in Fermenting Yeast

Inorganic pyrophosphatases are required for anabolism to take place in all living organisms. Defects in genes encoding these hydrolytic enzymes are considered inviable, although their exact nature has not been studied at the cellular and molecular physiology levels. Using a conditional mutant in IPP...

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Bibliographische Detailangaben
Hauptverfasser: Serrano-Bueno, Gloria, Hernández, Agustín, López-Lluch, Guillermo, Pérez-Castiñeira, José Román, Navas, Plácido, Serrano, Aurelio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642350/
https://ncbi.nlm.nih.gov/pubmed/23479727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439349
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