Excitation and Modulation of TRPA1, TRPV1, and TRPM8 Channel-expressing Sensory Neurons by the Pruritogen Chloroquine

The sensations of pain, itch, and cold often interact with each other. Pain inhibits itch, whereas cold inhibits both pain and itch. TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 transduces cold. The pruritogen chloroquine (CQ) was reported to excite TRPA1, leading to the sensation...

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Bibliografiske detaljer
Main Authors: Than, Jonathan Y.-X. L., Li, Lin, Hasan, Raquibul, Zhang, Xuming
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642326/
https://ncbi.nlm.nih.gov/pubmed/23508958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.450072
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