Competitive and Non-competitive Regulation of Calcium-dependent Inactivation in Ca(V)1.2 L-type Ca(2+) Channels by Calmodulin and Ca(2+)-binding Protein 1

Ca(V)1.2 interacts with the Ca(2+) sensor proteins, calmodulin (CaM) and calcium-binding protein 1 (CaBP1), via multiple, partially overlapping sites in the main subunit of Ca(V)1.2, α(1C). Ca(2+)/CaM mediates a negative feedback regulation of Ca(v)1.2 by incoming Ca(2+) ions (Ca(2+)-dependent inact...

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Detalhes bibliográficos
Main Authors: Oz, Shimrit, Benmocha, Adva, Sasson, Yehezkel, Sachyani, Dana, Almagor, Lior, Lee, Amy, Hirsch, Joel A., Dascal, Nathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642314/
https://ncbi.nlm.nih.gov/pubmed/23530039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.460949
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