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Competitive and Non-competitive Regulation of Calcium-dependent Inactivation in Ca(V)1.2 L-type Ca(2+) Channels by Calmodulin and Ca(2+)-binding Protein 1
Ca(V)1.2 interacts with the Ca(2+) sensor proteins, calmodulin (CaM) and calcium-binding protein 1 (CaBP1), via multiple, partially overlapping sites in the main subunit of Ca(V)1.2, α(1C). Ca(2+)/CaM mediates a negative feedback regulation of Ca(v)1.2 by incoming Ca(2+) ions (Ca(2+)-dependent inact...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3642314/ https://ncbi.nlm.nih.gov/pubmed/23530039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.460949 |
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