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Ligand-independent Tie2 Dimers Mediate Kinase Activity Stimulated by High Dose Angiopoietin-1
Tie2 is a receptor tyrosine kinase expressed on vascular endothelial cells (ECs). It has dual roles in promoting angiogenesis and stabilizing blood vessels, and it has been suggested that Tie2 forms dimers and/or oligomers in the absence of angiopoietin-1 (Ang1); however, the mechanism of ligand-ind...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3642295/ https://ncbi.nlm.nih.gov/pubmed/23504320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.433979 |
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