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Ligand-independent Tie2 Dimers Mediate Kinase Activity Stimulated by High Dose Angiopoietin-1

Tie2 is a receptor tyrosine kinase expressed on vascular endothelial cells (ECs). It has dual roles in promoting angiogenesis and stabilizing blood vessels, and it has been suggested that Tie2 forms dimers and/or oligomers in the absence of angiopoietin-1 (Ang1); however, the mechanism of ligand-ind...

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Hlavní autoři: Yamakawa, Daishi, Kidoya, Hiroyasu, Sakimoto, Susumu, Jia, Weizhen, Naito, Hisamichi, Takakura, Nobuyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642295/
https://ncbi.nlm.nih.gov/pubmed/23504320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.433979
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