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Activation of HIF2α in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but Not Tumorigenesis
Renal cell carcinoma (RCC) is the most common primary cancer arising from the kidney in adults, with clear cell carcinoma (ccRCC) representing ~75% of all RCCs. Increased expression of the hypoxia-induced factors HIF1α and HIF2α has been suggested as a pivotal step in ccRCC carcinogenesis, but this...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3642229/ https://ncbi.nlm.nih.gov/pubmed/23447580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3983 |
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