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Shifting from the single- to the multitarget paradigm in drug discovery
Increasing evidence that several drug compounds exert their effects through interactions with multiple targets is boosting the development of research fields that challenge the data reductionism approach. In this article, we review and discuss the concepts of drug repurposing, polypharmacology, chem...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3642214/ https://ncbi.nlm.nih.gov/pubmed/23340113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2013.01.008 |
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