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PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells
Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1–siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochr...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3642168/ https://ncbi.nlm.nih.gov/pubmed/23650610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2012.09.001 |
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