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Evolution of an inhibitory RNA aptamer against T7 RNA polymerase

Aptamers are promising gene components that can be used for the construction of synthetic gene circuits. In this study, we isolated an RNA aptamer that specifically inhibits transcription of T7 RNA polymerase (RNAP). The 38-nucleotide aptamer, which was a shortened variant of an initial SELEX isolat...

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Autori principali: Ohuchi, Shoji, Mori, Yusuke, Nakamura, Yoshikazu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642155/
https://ncbi.nlm.nih.gov/pubmed/23650601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2012.07.004
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