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The Novel Ubiquitin Ligase Complex, SCF(Fbxw4), Interacts with the COP9 Signalosome in an F-Box Dependent Manner, Is Mutated, Lost and Under-Expressed in Human Cancers

Identification of novel proteins that can potentially contribute to carcinogenesis is a requisite venture. Herein, we report the first biochemical characterization of the novel F-box and WD40 containing protein, FBXW4. We have identified interacting protein partners and demonstrated that FBXW4 is pa...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Lockwood, William W., Chandel, Sahiba K., Stewart, Greg L., Erdjument-Bromage, Hediye, Beverly, Levi J.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642104/
https://ncbi.nlm.nih.gov/pubmed/23658844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063610
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