Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

Clinical management of cancer patients could be improved through the development of noninvasive approaches for the detection of incipient, residual, and recurrent tumors. We describe an approach to directly identify tumor-derived chromosomal alterations through analysis of circulating cell-free DNA...

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Главные авторы: Leary, Rebecca J., Sausen, Mark, Kinde, Isaac, Papadopoulos, Nickolas, Carpten, John D., Craig, David, O’Shaughnessy, Joyce, Kinzler, Kenneth W., Parmigiani, Giovanni, Vogelstein, Bert, Diaz, Luis A., Velculescu, Victor E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641759/
https://ncbi.nlm.nih.gov/pubmed/23197571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004742
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