Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

Oroxylin A is a major active component of the Chinese traditional medicinal plant Scutellaria baicalensis Georgi, which has been reported as a potential anticancer drug. We demonstrated that, Oroxylin A inhibited the glycolysis and the binding of hexokinase II (HK II) with mitochondria in human brea...

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Bibliografiske detaljer
Main Authors: Wei, L, Zhou, Y, Dai, Q, Qiao, C, Zhao, L, Hui, H, Lu, N, Guo, Q-L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641353/
https://ncbi.nlm.nih.gov/pubmed/23598413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.131
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