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Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
We demonstrate that the transition from a reliance on glycolysis to oxidative phosphorylation in a transformed cell line is dependent on an increase in the levels and activity of sirtuin-3. Sirtuin-3 deacetylates cyclophilin D, diminishing its peptidyl-prolyl cis-trans isomerase activity and inducin...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3189253/ https://ncbi.nlm.nih.gov/pubmed/20159966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.061846 |
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