Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause Toll-like receptor 4 activation and enhanced pain

We have previously observed that the non-opioid morphine metabolite, morphine-3-glucuronide, enhances pain via a toll-like receptor 4 (TLR4) dependent mechanism. The present studies were undertaken to determine whether TLR4-dependent pain enhancement generalizes to other classes of glucuronide metab...

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Detalhes bibliográficos
Main Authors: Lewis, Susannah S., Hutchinson, Mark R., Zhang, Yingning, Hund, Dana K., Maier, Steven F., Rice, Kenner C., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641160/
https://ncbi.nlm.nih.gov/pubmed/23348028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2013.01.005
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