Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene

BACKGROUND: Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced. It is also subject to RNA editing in the intestine, which generates a shortened is...

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Autores principales: Srirangalingam, Umasuthan, Akker, Scott A, Norman, Dennis, Navaratnam, Naveenan, Chew, Shern L, Khoo, Bernard
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640928/
https://ncbi.nlm.nih.gov/pubmed/23391187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-14-5
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