Frizzled receptors signal through G proteins

Frizzled receptors have long been thought to couple to G proteins but biochemical evidence supporting such an interaction has been lacking. Here we expressed mammalian Wnt-Frizzled fusion proteins in Saccharomyces cerevisiae and tested the receptors’ ability to activate the yeast mitogen-activated p...

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Hauptverfasser: Nichols, Andrea S., Floyd, Desiree H., Bruinsma, Stephen P., Narzinski, Kirk, Baranski, Thomas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640709/
https://ncbi.nlm.nih.gov/pubmed/23524329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.03.009
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