Mice Deficient in Glycerol-3-Phosphate Acyltransferase-1 Have a Reduced Susceptibility to Liver Cancer

The risk of hepatocellular carcinoma increases with the persistence of non-alcoholic fatty liver disease. Triacylglycerol synthesis is initiated by glycerol-3-phosphate acyltransferase (GPAT). Of four isoforms, GPAT1 contributes 30–50% of total liver GPAT activity, and we hypothesized that it might...

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Detalhes bibliográficos
Main Authors: Ellis, Jessica M., Paul, David S., Depetrillo, Michael A., Singh, Bhanu P., Malarkey, David E., Coleman, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640291/
https://ncbi.nlm.nih.gov/pubmed/22215515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623311432298
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