The Contraceptive Depot Medroxyprogesterone Acetate Impairs Mycobacterial Control and Inhibits Cytokine Secretion in Mice Infected with Mycobacterium tuberculosis

The contraceptive depot medroxyprogesterone acetate (DMPA), with progestin as the single active compound, possesses selective glucocorticoid activity and can alter the expression of glucocorticoid receptor-regulated genes. We therefore propose that pharmacological doses of DMPA used for endocrine th...

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Detalhes bibliográficos
Main Authors: Kleynhans, Léanie, Du Plessis, Nelita, Allie, Nasiema, Jacobs, Muazzam, Kidd, Martin, van Helden, Paul D., Walzl, Gerhard, Ronacher, Katharina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639598/
https://ncbi.nlm.nih.gov/pubmed/23381991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01189-12
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