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The Role of Protein Interactions in Mediating Essentiality and Synthetic Lethality
Genes are characterized as essential if their knockout is associated with a lethal phenotype, and these “essential genes” play a central role in biological function. In addition, some genes are only essential when deleted in pairs, a phenomenon known as synthetic lethality. Here we consider genes di...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3639263/ https://ncbi.nlm.nih.gov/pubmed/23638160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062866 |
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