Kalirin Promotes Neointimal Hyperplasia by Activating Rac in Smooth Muscle Cells

OBJECTIVE: Kalirin is a multifunctional protein that contains two guanine nucleotide exchange factor (GEF) domains for the GTPases Rac1 and RhoA. Variants of KALRN have been associated with atherosclerosis in humans, but Kalirin’s activity has been characterized almost exclusively in the CNS. We the...

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Main Authors: Wu, Jiao-Hui, Fanaroff, Alexander C., Sharma, Krishn C., Smith, Liisa S., Brian, Leigh, Eipper, Betty A., Mains, Richard E., Freedman, Neil J., Zhang, Lisheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638886/
https://ncbi.nlm.nih.gov/pubmed/23288169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300234
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