Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

[Image: see text] Castrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer. CRPC is characterized by reactivation of the androgen axis due to changes in androgen receptor signaling and/or adaptive intratumoral androgen biosynthesis. AKR1C3 is upregulated in CRPC where...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Liedtke, Andy J., Adeniji, Adegoke O., Chen, Mo, Byrns, Michael C., Jin, Yi, Christianson, David W., Marnett, Lawrence J., Penning, Trevor M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2013
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638264/
https://ncbi.nlm.nih.gov/pubmed/23432095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3017656
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים