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Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF

Glial cell-line derived neurotrophic factor (GDNF) has been established as a growth factor for the survival and maintenance of dopamine (DA) neurons. In phase I clinical trials, GDNF treatment in Parkinson’s disease patients led to improved motor function and GDNF has been found to be down regulated...

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Главные авторы: Littrell, Ofelia M., Granholm, Ann-Charlotte, Gerhardt, Greg A., Boger, Heather A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638246/
https://ncbi.nlm.nih.gov/pubmed/23290934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2012.12.022
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