Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions

Regulatory elements recruit transcription factors that modulate gene expression distinctly across cell types, but the relationships among these remains elusive. To address this, we analyzed matched DNase-seq and gene expression data for 112 human samples representing 72 cell types. We first defined...

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Detalhes bibliográficos
Main Authors: Sheffield, Nathan C., Thurman, Robert E., Song, Lingyun, Safi, Alexias, Stamatoyannopoulos, John A., Lenhard, Boris, Crawford, Gregory E., Furey, Terrence S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638134/
https://ncbi.nlm.nih.gov/pubmed/23482648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.152140.112
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