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Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of ALS mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons and oligodendrocyte progenitors (NG2(+) cells) exhibit enhanced proliferation...

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Bibliografische gegevens
Hoofdauteurs: Kang, Shin H., Li, Ying, Fukaya, Masahiro, Lorenzini, Ileana, Cleveland, Don W., Ostrow, Lyle W., Rothstein, Jeffrey D., Bergles, Dwight E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637847/
https://ncbi.nlm.nih.gov/pubmed/23542689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3357
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