טוען...
Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency
Affinity improvement of proteins, including antibodies, by computational chemistry broadly relies on physics-based energy functions coupled with refinement. However, achieving significant enhancement of binding affinity (>10-fold) remains a challenging exercise, particularly for cross-reactive an...
שמור ב:
| Main Authors: | , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3637786/ https://ncbi.nlm.nih.gov/pubmed/23569282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303645110 |
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